Partially inspired by Monster Hunter and Shadow of the Colossus, The Hunters will be a traditional fantasy RPG with the players assuming the role of Dragon Chasers, courageous adventurers who travel the land to observe, study and stop / kill dragons and other titanic monsters who stray too close to human civilizations.
Dragons and other creatures are treated as natural disasters, and it’s up to the player characters and their know-how and courage to find ways to stop them from causing massive damage to the human population. One part storm-chasing and national geographic to one part monster hunter, the game will revolve around phases centered on study and observation (and survival) and coming up with a plan of action to stop or kill the offending monster.
Add rival guilds, opposing kingdoms, and the rediscovery of Beast Magic that can control such things and you get the opportunity to spin the game off into a more political campaign while still keeping the monster hunting core of the campaign.
I can see this campaign working very well with Fantasy Craft, but HERO can certainly pull this off as well.