They don’t call it the World of Darkness just because it’s ripe for angst and tragedy. it’s also a vicious, dangerous place where the meek hide from predators, human and otherwise. It’s easy to be a victim in the World of Darkness, so it’s always a good thing to know how to fight.
Mechanically speaking of course.
That being said, it’s easy enough to see the more… direct route of fighting in nWoD, just try to be the one with a higher dice pool, but here are a few options that might just make the difference between limping home alive, or dying from blood loss in a dark alley somewhere.